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Sains Malaysiana 53(4)(2024): 851-868
http://doi.org/10.17576/jsm-2024-5304-10
A Vortex-Assisted Deep Eutectic Solvent for Parabens
Extraction in Cosmetic Samples Coupled with High Performance Liquid
Chromatography
(Pelarut Eutektik Dalam Berbantu Vortex untuk Pengekstrakan Paraben dalam Sampel Kosmetik Digandingkan dengan Kromatografi Cecair Berprestasi Tinggi)
NURIN FARAWANI BINTI
MUHAMAD YUSRI, NOORASHIKIN BINTI MD SALEH*, TANUSHA DEVI A/P ELAN
SOLAN & MUHAMMAD ZULHAZIMAN MAT SALLEH
Department of Chemical and
Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia,
43600 UKM Bangi, Selangor, Malaysia
Diserahkan: 8 Januari2023/Diterima: 13 Mac 2024
Abstract
Parabens,
commonly used preservatives in food, cosmetics, and pharmaceutical items,
inhibit harmful germ growth. Deep Eutectic Solvents (DES) are intriguing for
analyte extraction due to superior properties formed through hydrogen bond
acceptors and donor interactions. However, the studies on the optimal DES-based
extraction conditions for paraben-containing cosmetics and the accuracy of
'paraben-free' labels are limited. The most effective DES (DL-Menthol and
decanoic acid, 1:2 molar ratio) was applied to cosmetic samples after heating
at 80 °C following optimization parameters. FTIR study confirmed hydrogen bonds
in DES samples. Both paraben-containing and paraben-free samples showed methyl,
ethyl, and propyl paraben peaks from the HPLC analysis. Cosmetic sample paraben
concentrations ranged from 0.53 mg/L to 26.08 mg/L (non-spiked). LOD and LOQ
were 0.24 mg/L-1.62 mg/L, 0.73 mg/L, and 4.8 mg/L, respectively. Goals were met
by establishing a paraben extraction method using DES and investigating paraben quantities in cosmetics.
Keywords: Cosmetic; deep eutectic solvent; high
performance liquid chromatography; paraben; vortex
Abstrak
Paraben,
bahan pengawet yang biasa digunakan dalam makanan, kosmetik dan bahan
farmaseutikal, merencat pertumbuhan kuman berbahaya. Pelarut Eutektik (DES)
menarik minat untuk pengekstrakan analit kerana sifat unggul yang terbentuk
melalui interaksi penerima dan penderma ikatan hidrogen. Namun, kajian
pengekstrakan menggunakan DES yang optimum untuk kosmetik mengandungi paraben
dan ketepatan label 'bebas paraben' masih terhad. DES yang paling berkesan
(DL-Menthol dan asid dekanoik, nisbah molar 1:2) digunakan pada sampel kosmetik
selepas dipanaskan pada 80 °C mengikut pengoptimuman parameter. Kajian FTIR
mengesahkan kewujudan ikatan hidrogen dalam sampel DES. Analisis HPLC
menunjukkan puncak metil, etil dan propil paraben sama ada sampel mengandungi
paraben atau bebas paraben. Kepekatan paraben dalam sampel kosmetik adalah
dalam julat 0.53 mg/L hingga 26.08 mg/L (tidak disuntik dengan paraben). LOD
dan LOQ masing-masing adalah 0.24 mg/L-1.62 mg/L, 0.73 mg/L, dan 4.8 mg/L.
Matlamat telah tercapai dengan membentuk kaedah pengekstrakan paraben yang
berkesan menggunakan DES dan mengkaji kuantiti paraben dalam kosmetik.
Kata kunci: Kosmetik; kromatografi cecair berprestasi tinggi; paraben; pelarut eutektik; vortex
Antakli, S., Kabani, R. & Shawa, D. 2013.
Determination of preservative parabens in oral and injection formulations by
HPLC. Asian Journal of Chemistry 25(2): 1123-1128.
Ariffin, M.M., Sohaimi, N.M., Yih, B.S. &
Saleh, N.M. 2019. Magnetite nanoparticles coated with surfactant Sylgard 309 and its application as an adsorbent for paraben
extraction from pharmaceutical and water samples. Analytical Methods 11(32): 4126-4136.
Bazmandegan-Shamili, A., Dadfarnia, S., Shabani, A.M.H., Moghadam, M.R. & Saeidi, M.
2018. Temperature-controlled liquid-liquid microextraction combined with high-performance liquid chromatography for the simultaneous
determination of diazinon and fenitrothion in water and fruit juice samples. Journal of Separation Science 41(11):
2411-2418.
Beh, S.Y., Mahfut,
I.W.B.D., Juber, N.I.B.M., Asman,
S., Yusoff, F. & Saleh, N.M. 2021. Extraction of
parabens from cosmetic and environmental water samples coupled with UV-visible
spectroscopy. Journal of Applied Spectroscopy 87: 1216-1223.
Dalmaz, A. & Özak,
S.S. 2022. DES-based vortex-assisted liquid-liquid microextraction procedure developed for the determination of paraben preservatives in
mouthwashes. Microchemical Journal 179:
107445.
Dwamena, A.K. 2019.
Recent advances in hydrophobic deep eutectic solvents for extraction. Separations 6(1): 9.
El-Deen, A.K. & Shimizu, K. 2021. Deep eutectic solvents
as promising green solvents in dispersive liquid-liquid microextraction based on solidification of floating organic droplet: Recent applications,
challenges and future perspectives. Molecules 26(23): 7406.
FDA. 2022.
Parabens in Cosmetics | FDA.
Florindo, C., Branco, L.C. & Marrucho, I.M.
2019. Quest for green-solvent design: From hydrophilic to hydrophobic (Deep)
eutectic solvents. ChemSusChem 12(8):
1549-1559.
Florindo, C., Branco, L.C. & Marrucho, I.M.
2017. Development of hydrophobic deep eutectic solvents for extraction of
pesticides from aqueous environments. Fluid Phase Equilibria 448:
135-142.
Ge, D., Gao,
Y., Cao, Y., Dai, E. & Yuan, L. 2020. Preparation of a new polymeric deep eutectic
solvent and its application in vortex-assisted liquid-liquid microextraction of parabens in foods, cosmetics and
pharmaceutical products. Journal of the Brazilian Chemical Society 31(10): 2120-2128.
Ge, D.,
Wang, Y., Jiang, Q. & Dai, E. 2019. A deep eutectic solvent as an
extraction solvent to separate and preconcentrate parabens in water samples using in situ liquid-liquid microextraction. Journal of the Brazilian Chemical
Society 30(6): 1203-1210.
Gosens, I., Delmaar, C.J.E., Ter Burg, W., De Heer, C. & Schuur, A.G. 2013. Aggregate exposure
approaches for parabens in personal care products: A case assessment for
children between 0 and 3 years old. Journal of Exposure Science &
Environmental Epidemiology 24(2): 208-214.
Hikmawanti, N.P.E., Ramadon,
D., Jantan, I. & Mun’im,
A. 2021. Natural deep eutectic solvents (NADES): Phytochemical extraction
performance enhancer for pharmaceutical and nutraceutical product
development. Plants 10(10): 2091.
Jala, A., Dutta, R., Josyula,
J.V.N., Mutheneni, S.R. & Borkar,
R.M. 2023. Environmental phenol exposure associates with urine metabolome
alteration in young Northeast Indian females. Chemosphere 317:
137830.
Kolesov, B.A. 2021.
Hydrogen bonds: Raman spectroscopic study. International Journal of
Molecular Sciences 22(10): 5380.
Li, T.,
Song, Y., Li, J., Zhang, M., Shi, Y. & Fan, J. 2020. New low viscous
hydrophobic deep eutectic solvents in vortex-assisted liquid-liquid microextraction for the determination of phthalate esters
from food-contacted plastics. Food Chemistry 309: 125752.
Mishra, R.K., Mentha,
S.S., Misra, Y. & Dwivedi,
N. 2023. Emerging pollutants of severe environmental concern in water and
wastewater: A comprehensive review on current developments and future
research. Water-Energy Nexus 6: 74-95.
Özak, S.S. 2020.
A vortex-assisted microextraction based on deep
eutectic solvents for determination of four parabens from cosmetic baby oils
and optimization by Box-Behnken design. Duzce University Journal of Science and
Technology 8(3): 1936-1947.
Polaka, S., Gomte, S.S., Pandey, V., Tella,
J.D., Tekade, M., Sharma, M.C., Molugulu,
N. & Tekade, R.K. 2022. Pharmaceutical
excipients: Special focus on adverse interactions. Pharmacokinetics and Toxicokinetic Considerations - Vol II: Advances in
Pharmaceutical Product Development and Research, edited by Tekade, R.K. Massachusetts: Academic Press. pp. 513-542.
Razavi, N., Foroutan, F., Sahebian, S. &
Khaki, J.V. 2022. Extraction and pre-concentration of parabens in liquid
pharmaceutical samples by dispersive liquid-liquid microextraction based on deep eutectic solvent. Biomedical Chromatography 37(2): e5547.
Shah, D.
& Mjalli, F.S. 2014. Effect of water on the
thermo-physical properties of Reline: An experimental and molecular simulation
based approach. Physical Chemistry Chemical Physics 16(43): 23900-23907.
Shamsuri, A. & Kuang, A. 2010. Ionic liquids: Preparations and
limitations. MAKARA of Science Series 14(2): 101-106.
Sivrikaya, S. 2019. A
novel vortex-assisted liquid phase microextraction method for parabens in cosmetic oil products using deep eutectic solvent. International
Journal of Environmental Analytical Chemistry 99(15): 1575-1585.
Smith, E.L.,
Abbott, A.P. & Ryder, K.S. 2014. Deep eutectic solvents (DESs) and their
applications. Chemical Reviews 114(21): 11060-11082.
Temova Rakuša,
Ž., Škufca, P., Kristl, A.
& Roškar, R. 2021. Retinoid stability and
degradation kinetics in commercial cosmetic products. Journal of
Cosmetic Dermatology 20(7): 2350-2358.
Yih, B.S., Sohaimi,
N.M., Aziz, H.B.Z., Zaini, S.R.B.M., Suda, N.B., Kandasamy, S., Subramaniam, K.V.N., Bajuri,
F.N.A.B. & Saleh, N.M. 2019. Development of cloud point extraction for
parabens using different surfactants with modifiers. Materials Today:
Proceedings 19: 1787-1795.
Yıldız, E. & Çabuk, H. 2018. Miniaturized matrix solid-phase dispersion
coupled with supramolecular solvent-based microextraction for the determination of paraben preservatives in cream samples. Journal of
Separation Science 41(13): 2750-2758.
*Pengarang untuk surat-menyurat;
email: noorashikin@ukm.edu.my
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